nanoknife ablation in retroperitoneal tumor

Objective: This present study was aimed to assess the effectiveness and reliability of CT-guided nanoknife ablation in retroperitoneal tumor treatment. Methods: 2 retroperitoneal tumor patients were selected, including one pancreatic cancer patient and one colorectal cancer retroperitoneal metastatic tumor patient. The surgery was performed under general anesthesia with large aperture multi-slice CT, electrocardio synchroscope and anesthesia monitoring device. Nanoknife ablation electrode was implanted through percutaneous conformal puncture in accordance with preoperative plan and ablation degrees were estimated by current waveform. It was significant to perform CT examination immediately to eliminate complications and monitor patients’ vital signs continuously and comprehensively after surgery. Imaging test was implemented to observe curative effects and complications 3-5 days after surgery and each laboratory examination of blood needed to be reviewed. Results: 2 cases of surgery were completed successfully and the vital signs of patients were stable. Pancreatic cancer patient underwent mild abdominal pain without any severe complications after surgery. Imaging test displayed complete ablation, clear border, no intensification in ablation area, mild inflammatory change around and no damages on nearby blood vessels, biliopancreatic ducts and intestinal canals. The pancreatic cancer patient showed transient rises of lipase and diastase and mild rise of tumor marker via laboratory examination. There was no abnormality in laboratory index of retroperitoneal metastasis patient. Conclusion: Nanoknife ablation could protect blood vessels, biliopancreatic ducts and intestinal canals while inactivating tumors in the process of retroperitoneal tumor ablation. This technique was safe and effective, which might be further popularized and applied clinically.